Alcohol and pregnancy: Effects on maternal care, HPA axis function, and hippocampal neurogenesis in adult females

Psychoneuroendocrinology. 2015 Jul;57:37-50. doi: 10.1016/j.psyneuen.2015.03.001. Epub 2015 Mar 9.

Abstract

Chronic alcohol consumption negatively affects health, and has additional consequences if consumption occurs during pregnancy as prenatal alcohol exposure adversely affects offspring development. While much is known on the effects of prenatal alcohol exposure in offspring less is known about effects of alcohol in dams. Here, we examine whether chronic alcohol consumption during gestation alters maternal behavior, hippocampal neurogenesis and HPA axis activity in late postpartum female rats compared with nulliparous rats. Rats were assigned to alcohol, pair-fed or ad libitum control treatment groups for 21 days (for pregnant rats, this occurred gestation days 1-21). Maternal behavior was assessed throughout the postpartum period. Twenty-one days after alcohol exposure, we assessed doublecortin (DCX) (an endogenous protein expressed in immature neurons) expression in the dorsal and ventral hippocampus and HPA axis activity. Alcohol consumption during pregnancy reduced nursing and increased self-directed and negative behaviors, but spared licking and grooming behavior. Alcohol consumption increased corticosterone and adrenal mass only in nulliparous females. Surprisingly, alcohol consumption did not alter DCX-expressing cell density. However, postpartum females had fewer DCX-expressing cells (and of these cells more immature proliferating cells but fewer postmitotic cells) than nulliparous females. Collectively, these data suggest that alcohol consumption during pregnancy disrupts maternal care without affecting HPA function or neurogenesis in dams. Conversely, alcohol altered HPA function in nulliparous females only, suggesting that reproductive experience buffers the long-term effects of alcohol on the HPA axis.

Keywords: Alcohol; Corticosterone; Doublecortin; Maternal behavior; Postpartum; Reproductive experience.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alcohol Drinking / adverse effects*
  • Animals
  • Ethanol / toxicity*
  • Female
  • Hypothalamo-Hypophyseal System / drug effects*
  • Hypothalamo-Hypophyseal System / physiopathology
  • Male
  • Microtubule-Associated Proteins / metabolism
  • Models, Animal
  • Neurogenesis / drug effects
  • Neuropeptides / metabolism
  • Pituitary-Adrenal System / drug effects*
  • Pituitary-Adrenal System / physiopathology
  • Pregnancy
  • Prenatal Exposure Delayed Effects
  • Random Allocation
  • Rats
  • Rats, Sprague-Dawley

Substances

  • Microtubule-Associated Proteins
  • Neuropeptides
  • doublecortin protein
  • Ethanol