Oral lichen planus patients exhibit consistent chromosomal numerical aberrations: A follow-up analysis

Head Neck. 2016 Apr;38 Suppl 1:E741-6. doi: 10.1002/hed.24086. Epub 2015 Jul 30.


Background: Oral lichen planus (OLP) carries an increased risk for malignant transformation with aneuploid cells (ACs) being found in brush samples of a quarter of patients with OLP.

Methods: Patients with OLP were followed and repeated brush samples were simultaneously analyzed for morphology and fluorescent in situ hybridization (FISH) using centromeric probes for chromosomes 2 and 8.

Results: Three patients with a high proportion of ACs developed oral cancer. Fifteen patients had ≥1% ACs (13 in affected sites and 2 in nonaffected sites), whereas only 2 of the 15 patients with <1% ACs in the first sample had ≥1% ACs in the second sample. A strong positive correlation between the results of the initial and repeated samples was found.

Conclusion: High proportion of ACs in brush samples from patients with OLP may imply an impending malignant transformation. As FISH analysis is consistent over time, it can be used to identify a subgroup of patients who would require close follow-up. © 2015 Wiley Periodicals, Inc. Head Neck 38: E741-E746, 2016.

Keywords: aneuploidy; chromosomal instability; oral cancer; oral lichen planus.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Aneuploidy*
  • Cell Transformation, Neoplastic
  • Chromosomes, Human, Pair 2 / genetics
  • Chromosomes, Human, Pair 8 / genetics
  • Female
  • Follow-Up Studies
  • Humans
  • In Situ Hybridization, Fluorescence
  • Lichen Planus, Oral / genetics*
  • Lichen Planus, Oral / pathology
  • Male
  • Middle Aged
  • Mouth Neoplasms / genetics
  • Mouth Neoplasms / pathology*