Association between Cardiorespiratory Fitness and Health-Related Quality of Life among Patients at Risk for Cardiovascular Disease in Uruguay

PLoS One. 2015 Apr 22;10(4):e0123989. doi: 10.1371/journal.pone.0123989. eCollection 2015.


Purpose: To examine the association between objectively measured CRF and physical and mental components of HRQoL in a Uruguayan cohort at risk for developing CVD.

Methods: Patient data records from 2002-2012 at the Calidad de Vida Center were examined. To assess CRF, participants performed a submaximal exercise test. During the evaluation, participants also completed the SF-36, a HRQoL measure comprised of eight dimensions that are summarized by physical and mental component scores (PCS and MCS, respectively). ANCOVA was used to examine the relationship between HRQoL dimensions and CRF. Logistic regression was then used to compare the odds of having a HRQoL component score above the norm across CRF. All analyses were performed separately for males and females with additional stratified analyses across age and BMI conducted among significant trends.

Results: A total of 2,302 subjects were included in the analysis. Among females, a significant relationship was observed between CRF and vitality, physical functioning, physical role, bodily pain, and general health dimensions. However, for males the only dimension found to be significantly associated with CRF was physical health. After adjusting for potential confounders, a significant linear trend (p<0.001) for PCS scores above the norm across CRF levels was observed for females only.

Conclusion: Among females with one or more risk factors for developing CVD, higher levels of CRF were positively associated with the vitality and physical dimensions of HRQoL, as well as the overall PCS. However, among males the only dimension associated with CRF was physical functioning. Future studies should examine this relationship among populations at risk for developing CVD in more detail and over time.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cardiovascular Diseases / epidemiology*
  • Cardiovascular Diseases / physiopathology*
  • Cardiovascular Physiological Phenomena*
  • Cross-Sectional Studies
  • Female
  • Health Status*
  • Humans
  • Male
  • Middle Aged
  • Physical Fitness*
  • Quality of Life*
  • Respiratory Physiological Phenomena*
  • Risk
  • Surveys and Questionnaires
  • Uruguay / epidemiology

Grants and funding

Funding for this project was provided through an unrestricted grant from the La Banca Company in Uruguay. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.