The effects of caffeic acid phenethyl ester on inflammatory cytokines after acute spinal cord injury

Ulus Travma Acil Cerrahi Derg. 2015 Mar;21(2):96-101. doi: 10.5505/tjtes.2015.33848.


Background: The purpose of this study was to investigate the effects of Caffeic Acid Phenethyl Ester (CAPE) on proinflammatory cytokines, IL-1ß and TNF-α, and explore its healing effect after acute spinal cord injury.

Methods: Forty-eight male Wistar-Albino rats were used in this study which was planned as three groups. All groups were divided into two sub-groups. Group 1a was the control group, in which only lower segment thoracic laminectomy was performed. In group 1b, spinal cord trauma was performed with aneurysm clip. In the second group, serum physiologic was given systemically thirty minutes after trauma, and rats were sacrificed after the first and sixth hour. In the third group, CAPE was given systemically thirty minutes after trauma, and rats were sacrificed after the first and sixth hour. Serum IL-1ß and TNF-α levels were analyzed by ELISA in the serum. Histopathological analysis was performed in damaged cord tissues.

Results: CAPE suppressed TNF-α and IL-1ß levels in the serum. In histopathological evaluation, it was detected that CAPE decreased hemorrhage and necrosis.

Conclusion: CAPE suppresses the levels of proinflammatory cytokines, TNF-α and IL-1ß, after acute spinal cord injury in the early phase and contributes to the healing process.

MeSH terms

  • Animals
  • Caffeic Acids / administration & dosage
  • Caffeic Acids / pharmacology
  • Caffeic Acids / therapeutic use*
  • Cytokines / blood
  • Cytokines / drug effects
  • Interleukin-1beta / blood
  • Interleukin-1beta / drug effects
  • Male
  • Neuroprotective Agents / administration & dosage
  • Neuroprotective Agents / pharmacology
  • Neuroprotective Agents / therapeutic use*
  • Phenylethyl Alcohol / administration & dosage
  • Phenylethyl Alcohol / analogs & derivatives*
  • Phenylethyl Alcohol / pharmacology
  • Phenylethyl Alcohol / therapeutic use
  • Rats
  • Rats, Wistar
  • Spinal Cord Injuries / blood
  • Spinal Cord Injuries / drug therapy*
  • Tumor Necrosis Factor-alpha / blood
  • Tumor Necrosis Factor-alpha / drug effects


  • Caffeic Acids
  • Cytokines
  • Interleukin-1beta
  • Neuroprotective Agents
  • TNF protein, human
  • Tumor Necrosis Factor-alpha
  • caffeic acid phenethyl ester
  • Phenylethyl Alcohol