The tumors which comprise the MEN syndromes arise from APUD neuroendocrine cells. Each of the syndromes is inherited as an autosomal dominant trait. Advances in molecular biology and genetics have led to the identification of specific genetic defects which will improve the understanding and ability to diagnose these tumors. There are three distinct MEN syndromes as well as non-MEN familial medullary thyroid carcinoma.
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