Pancreatic neuroendocrine neoplasms (PNENs) are a heterogenous group of relatively rare pancreatic malignancies with a unique biology and pathophysiology. Over the last few years, there have been significant improvements in imaging and treatment strategies, which have led to advances in patient’s management and quality of life (QOL). Yet, in practice, there are still a number of unanswered questions. For example, it remains a challenge to choose the optimal treatment sequence from the plethora of options and to properly monitor PNEN patients. Therefore, in this chapter, recent advances in the pathophysiology, diagnosis, monitoring, and management of these neoplasms will be summarized and placed in a historical context. For complete coverage of all related areas of Endocrinology, please visit our on-line FREE web-text,
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