Sinus floor augmentation with autogenous bone vs. a bovine-derived xenograft - a 5-year retrospective study

Clin Oral Implants Res. 2015 Jun;26(6):644-8. doi: 10.1111/clr.12352. Epub 2014 Feb 20.


Objectives: The long-term outcome after sinus augmentation with autogenous bone or a bovine xenograft (Bio-Oss(®)) was assessed in 47 patients. Inclusion criterion was a vertical dimension of the maxilla of <4 mm. After a functional loading period of 60 months, implant survival and reduction in the augmentation height were compared between the two groups evaluated.

Material and methods: Sinus augmentation was performed using mandibular bone grafts or Bio-Oss(®). In the autogenous bone group, 70 implants were placed in 23 patients, while in the Bio-Oss(®) group, 24 patients received 98 implants. Fisher's exact test and equivalence testing were used to compare implant survival rates.

Results: The overall survival rate of the implants was 95.8% 5 years after implant insertion. In the autogenous bone group, the implants had a survival rate of 97.1%, while in the Bio-Oss(®) group, 94.9% of the implants survived. The difference was not statistically significant (P > 0.05); both treatments are equivalent (confidence interval 90%) for the equivalence interval [-0.1; 0.1]. 43.5% of the cases showed no reduction in the augmentation height 5 years after implant insertion, when augmentation was performed with autogenous bone, while in the Bio-Oss(®) group, no resorption was found in 50% of the augmented areas. Up to 25% reduction in augmentation height was found in 47.8% in the autogenous and in 45.8% in the Bio-Oss(®) group. In 8.7% of all cases in the autogenous bone group and in 4.2 % in the Bio-Oss(®) group, up to 50% of the augmented height was resorbed.

Conclusion: After a 5 years evaluation period, Bio-Oss(®) as material for the indication maxillary sinus augmentation shows to be equivalent to autogenous bone grafting.

Keywords: bone substitutes; clinical research; clinical trials; sinus floor elevation.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Animals
  • Bone Substitutes / therapeutic use*
  • Bone Transplantation / methods*
  • Cattle
  • Dental Implantation, Endosseous / methods*
  • Dental Implants
  • Female
  • Humans
  • Male
  • Mandible / surgery
  • Maxilla / surgery
  • Maxillary Sinus / surgery
  • Middle Aged
  • Minerals / therapeutic use*
  • Retrospective Studies
  • Sinus Floor Augmentation / methods*
  • Transplantation, Heterologous
  • Treatment Outcome
  • Young Adult


  • Bio-Oss
  • Bone Substitutes
  • Dental Implants
  • Minerals