Influence of Exercise on Inflammation in Cancer: Direct Effect or Innocent Bystander?

Exerc Sport Sci Rev. 2015 Jul;43(3):134-42. doi: 10.1249/JES.0000000000000054.

Abstract

We propose the hypothesis that the benefits of exercise on inflammation in cancer are a result of a direct effect on inflammatory cytokines, including interleukin-6, tumor necrosis factor-α, and monocyte chemoattractant protein 1, that are critical for cancer growth as well as a bystander effect of the established relationship between exercise and cancer.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Breast Neoplasms / physiopathology
  • Chemokine CCL2 / metabolism
  • Colonic Neoplasms / physiopathology
  • Cytokines / physiology*
  • Exercise / physiology*
  • Humans
  • Inflammation / physiopathology*
  • Interleukin-6 / metabolism
  • Neoplasms / immunology
  • Neoplasms / physiopathology*
  • Tumor Necrosis Factor-alpha / metabolism

Substances

  • Chemokine CCL2
  • Cytokines
  • IL6 protein, human
  • Interleukin-6
  • TNF protein, human
  • Tumor Necrosis Factor-alpha