Extra-CNS metastasis from glioblastoma: a rare clinical entity

Expert Rev Anticancer Ther. 2015 May;15(5):545-52. doi: 10.1586/14737140.2015.1028374.


Extra-CNS metastasis from glioblastoma (ECMGBM) is an emerging but little known clinical entity. We review pre-clinical and translational publications assessing the ability of GBM to spread locally and outside the CNS. Reported cases demonstrating ECMGBM are reviewed providing a summary of presentations for the entity. Special attention is placed on transmission of GBM through organ transplantation. Finally, predictions are made as to the future significance of ECMGBM, especially in the context of better outcomes in CNS GBM.

Keywords: circulating tumor cells; glioblastoma; gliomas; malignancy in transplant patients; organ transplantation.

Publication types

  • Review

MeSH terms

  • Animals
  • Brain Neoplasms / pathology*
  • Central Nervous System Neoplasms / pathology
  • Glioblastoma / pathology*
  • Humans
  • Neoplasm Metastasis / pathology*
  • Organ Transplantation / adverse effects