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Comment
. 2015 Apr 23;125(17):2591-3.
doi: 10.1182/blood-2015-03-630822.

Disabling the Platelet's Brakes to Promote Thrombosis

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Disabling the Platelet's Brakes to Promote Thrombosis

Roy L Silverstein. Blood. .

Abstract

In this issue of Blood, Magwenzi et al from the University of Hull report a novel mechanistic connection between oxidized low-density lipoprotein (oxLDL)-induced prothrombotic platelet signaling and the inhibition of endogenous platelet anti-activating signaling mediated by the nitric oxide (NO)/guanosine 3′,5′-cyclic monophosphate (cGMP)/protein kinase G (PKG) pathway.

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