Endovascular treatment of acute ischemic stroke

Neurol Clin. 2015 May;33(2):401-20. doi: 10.1016/j.ncl.2015.01.005. Epub 2015 Mar 17.


Endovascular therapy for acute stroke has evolved with the use of intra-arterial thrombolytics, intravenous/intra-arterial bridging strategies, and mechanical thrombectomy/aspiration devices. Despite widespread use in clinical practice, randomized trials of first-generation devices failed to demonstrate improved outcomes compared with standard care. New-generation stent retriever devices demonstrate higher rates of revascularization and clinical outcomes compared with first-generation devices. Additional randomized trials are underway and have the potential to confirm clinical efficacy of new-generation devices compared with standard care. The role of additional advanced imaging for patient selection remains unclear, and further trials are needed to demonstrate the role of these techniques for patient selection.

Keywords: Acute ischemic stroke; Computed tomography; Endovascular; MRI; Neuroimaging; Penumbra; Thrombolysis.

Publication types

  • Review

MeSH terms

  • Endovascular Procedures / methods*
  • Humans
  • Neuroimaging / methods
  • Stroke / therapy*
  • Thrombolytic Therapy / methods*