Treatment of severe mucogingival defects with a combination of strip gingival grafts and a xenogeneic collagen matrix: a prospective case series study

Int J Periodontics Restorative Dent. 2015 May-Jun;35(3):345-53. doi: 10.11607/prd.2287.


Large areas of mucogingival alterations may result from advanced regenerative procedures. This prospective case series study was performed to introduce and evaluate a surgical approach that combines the strip gingival graft technique with the use of a xenogeneic collagen matrix. The primary outcome measurement was the increase in keratinized tissue width from baseline to 12 months postprocedure. Twenty patients were enrolled, and they all completed the 12-month evaluation. All treated sites exhibited a significant gain in keratinized tissue at 12 months, with a mean width of 6.33 mm (SD: 2.16), while there was a 43% contraction of the grafted area at 6 months. Tissue dimensions remained stable between 6 and 12 months. The use of the combination graft was well accepted by the patients, with minimal morbidity according to the patients' low self-reported pain and the low utilization of pain medication.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alveolar Ridge Augmentation / adverse effects*
  • Collagen / therapeutic use*
  • Female
  • Gingiva / transplantation*
  • Gingivoplasty / methods*
  • Humans
  • Male
  • Middle Aged
  • Pain Measurement
  • Prospective Studies
  • Treatment Outcome
  • Vertical Dimension


  • Collagen