Macrophage activation: on par with LPS

Chem Biol. 2015 Apr 23;22(4):432-433. doi: 10.1016/j.chembiol.2015.04.006.


The inflammatory response is a critical component of the immune system that is activated by stimuli such as cytokines, foreign DNA, RNA, or other harmful substances. Krukenberg et al. (2015) identify poly(ADP-ribose) as a new signaling molecule that activates inflammation, thus providing yet another mechanism by which PARPs are involved in cellular stress responses.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Humans
  • Poly Adenosine Diphosphate Ribose / pharmacology*
  • Poly(ADP-ribose) Polymerases / metabolism*
  • Signal Transduction / drug effects*


  • Poly Adenosine Diphosphate Ribose
  • Poly(ADP-ribose) Polymerases