Macrophage activation: on par with LPS

Florian J Bock; Paul Chang

doi:10.1016/j.chembiol.2015.04.006

Macrophage activation: on par with LPS

Chem Biol. 2015 Apr 23;22(4):432-433. doi: 10.1016/j.chembiol.2015.04.006.

Authors

Florian J Bock¹, Paul Chang²

Affiliations

¹ Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA.
² Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA; Department of Biology, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA 02139, USA. Electronic address: pchang2@mit.edu.

PMID: 25910238
DOI: 10.1016/j.chembiol.2015.04.006

Abstract

The inflammatory response is a critical component of the immune system that is activated by stimuli such as cytokines, foreign DNA, RNA, or other harmful substances. Krukenberg et al. (2015) identify poly(ADP-ribose) as a new signaling molecule that activates inflammation, thus providing yet another mechanism by which PARPs are involved in cellular stress responses.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Humans
Poly Adenosine Diphosphate Ribose / pharmacology*
Poly(ADP-ribose) Polymerases / metabolism*
Signal Transduction / drug effects*

Substances

Poly Adenosine Diphosphate Ribose
Poly(ADP-ribose) Polymerases

Grants and funding

R01GM087465/GM/NIGMS NIH HHS/United States