DNA and RNA derivatives to optimize distribution and delivery

Adv Drug Deliv Rev. 2015 Jun 29:87:25-34. doi: 10.1016/j.addr.2015.04.012. Epub 2015 Apr 22.

Abstract

Synthetic, complementary DNA single strands and short interfering RNA double strands have been found to inhibit the expression of animal, plant, and viral genes in cells, animals, and patients, in a dose dependent and sequence specific manner. DNAs and RNAs, however, are readily digested in biological systems. Hence, chemists are obliged to design and synthesize nuclease-resistant analogs of normal DNA (Fig. 1).

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • DNA, Antisense* / administration & dosage
  • DNA, Antisense* / chemistry
  • DNA, Antisense* / pharmacology
  • Genetic Therapy*
  • Humans
  • RNA Interference / drug effects
  • RNA, Antisense* / administration & dosage
  • RNA, Antisense* / chemistry
  • RNA, Antisense* / pharmacology

Substances

  • DNA, Antisense
  • RNA, Antisense