The aging prostate is never "normal": implications from the genomic characterization of multifocal prostate cancers

Thorsten Schlomm; Joachim Weischenfeldt; Jan Korbel; Guido Sauter

doi:10.1016/j.eururo.2015.04.012

The aging prostate is never "normal": implications from the genomic characterization of multifocal prostate cancers

Eur Urol. 2015 Sep;68(3):348-50. doi: 10.1016/j.eururo.2015.04.012. Epub 2015 Apr 22.

Authors

Thorsten Schlomm¹, Joachim Weischenfeldt², Jan Korbel², Guido Sauter³

Affiliations

¹ Martini-Clinic, Prostate Cancer Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Electronic address: tschlomm@uke.de.
² Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
³ Institute of Pathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

PMID: 25913065
DOI: 10.1016/j.eururo.2015.04.012

Abstract

We argue against the recently published statement that tumor-specific molecular alterations found in "normal" prostate tissue from cancer patients challenge focal therapy approaches that only target a visible cancer lesion and not the adjacent molecular field.

Publication types

Editorial

MeSH terms

Aging / genetics*
Aging / metabolism
Genetic Heterogeneity
Genomics
Humans
Male
Neoplasms, Multiple Primary / genetics*
Neoplasms, Multiple Primary / metabolism
Oncogene Proteins, Fusion / metabolism
Prostate / metabolism*
Prostatic Neoplasms / genetics*
Prostatic Neoplasms / metabolism

Substances

Oncogene Proteins, Fusion
TMPRSS2-ERG fusion protein, human