Strategies to guide the antibody affinity maturation process

Curr Opin Virol. 2015 Apr;11:137-47. doi: 10.1016/j.coviro.2015.04.002. Epub 2015 Apr 24.

Abstract

Antibodies with protective activity are critical for vaccine efficacy. Affinity maturation increases antibody activity through multiple rounds of somatic hypermutation and selection in the germinal center. Identification of HIV-1 specific and influenza-specific antibody developmental pathways, as well as characterization of B cell and virus co-evolution in patients, has informed our understanding of antibody development. In order to counteract HIV-1 and influenza viral diversity, broadly neutralizing antibodies precisely target specific sites of vulnerability and require high levels of affinity maturation. We present immunization strategies that attempt to recapitulate these natural processes and guide the affinity maturation process.

Publication types

  • Research Support, N.I.H., Intramural
  • Review

MeSH terms

  • Antibodies, Viral / immunology*
  • Antibody Affinity*
  • Drug Discovery / methods
  • HIV-1 / immunology*
  • Humans
  • Orthomyxoviridae / immunology*
  • Vaccination / methods*
  • Viral Vaccines / immunology*
  • Viral Vaccines / isolation & purification*

Substances

  • Antibodies, Viral
  • Viral Vaccines