Abstract
Three new iridoids, cornifins A-C (1-3), together with a known iridoid, were obtained from EtOAc layer of leaves of Cornus officinalis. The structures of new compounds were elucidated on the basis of extensive spectroscopic analyses. Compound 2 showed weak inhibitory activity against lung cancer cell line A-549 with IC50 value of 29.1 μM.
Keywords:
Cornaceae; Cornus officinalis; cornifins A–C; iridoids; structure and cytotoxicity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Cornus / chemistry*
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Drug Screening Assays, Antitumor
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology
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Humans
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Iridoids / chemistry
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Iridoids / isolation & purification*
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Iridoids / pharmacology
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Plant Leaves / chemistry
Substances
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Antineoplastic Agents, Phytogenic
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Drugs, Chinese Herbal
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Iridoids
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cornifin A iridoid
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cornifin B iridoid
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cornifin C iridoid