Kaempferol, a dietary flavonoid, ameliorates acute inflammatory and nociceptive symptoms in gastritis, pancreatitis, and abdominal pain

Mol Nutr Food Res. 2015 Jul;59(7):1400-5. doi: 10.1002/mnfr.201400820. Epub 2015 Jun 5.


Kaempferol (KF) is the most abundant polyphenol in tea, fruits, vegetables, and beans. However, little is known about its in vivo anti-inflammatory efficacy and mechanisms of action. To study these, several acute mouse inflammatory and nociceptive models, including gastritis, pancreatitis, and abdominal pain were employed. Kaempferol was shown to attenuate the expansion of inflammatory lesions seen in ethanol (EtOH)/HCl- and aspirin-induced gastritis, LPS/caerulein (CA) triggered pancreatitis, and acetic acid-induced writhing.

Keywords: Abdominal pain; Anti-inflammatory effect; Gastritis; Kaempferol; Pancreatitis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abdominal Pain / drug therapy*
  • Acetic Acid / toxicity
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology
  • Aspirin / adverse effects
  • Ceruletide / adverse effects
  • Disease Models, Animal
  • Gastritis / chemically induced
  • Gastritis / drug therapy*
  • Gastritis / pathology
  • Kaempferols / pharmacology*
  • Mice
  • Nociception / drug effects*
  • Pancreatitis / chemically induced
  • Pancreatitis / drug therapy*


  • Anti-Inflammatory Agents, Non-Steroidal
  • Kaempferols
  • kaempferol
  • Ceruletide
  • Acetic Acid
  • Aspirin