Genetic variations in NFKB1 have been associated with cancer risk. This investigation intended to evaluate the possible association between common variants in NFKB1 and lung cancer risk and gene-gene and gene-environment interactions. A study containing 384 Chinese lung cancer cases and 387 cancer-free controls was conducted. 5 htSNPs (rs3774934, rs13117745, rs230541, rs1801, rs3774965) in NFKB1 and interaction with common variants in NFKB1 and PPP1R13L and CD3EAP and smoking-duration were assessed. No association with lung cancer risk was detected for individual htSNP in four genetic models, but the haplotype consisting of the wild-type alleles of rs3774934(G), rs13117745(C), rs230541(A), and rs1801(G) was associated with lowered lung cancer risk after adjustment for smoking duration [OR (95% CI) = 0.71 (0.51-0.98), P = 0.036]. There was no interaction between NFKB1 polymorphisms and PPP1R13L and CD3EAP and smoking status in relation to lung cancer risk. Two significant models: smoking duration as main effect (P < 0.0010) and smoking duration-PPP1R13L rs1970764 combination (P = 0.0040-0.0050) were tested. The results suggest that NFKB1 common variants and smoking duration and smoking duration-PPP1R13L rs1970764 interaction could be concerned with the lung cancer development in a Chinese population. The present findings add to the evidence implicating inflammation in lung cancer etiology.
Keywords: Chinese; Common variants; Interaction; Lung cancer; NFKB1 and PPP1R13L and CD3EAP.
Copyright © 2015 Elsevier B.V. All rights reserved.