Laryngeal Papillary Squamous Cell Carcinoma: A Population-Based Analysis of Incidence and Survival

Otolaryngol Head Neck Surg. 2015 Jul;153(1):54-9. doi: 10.1177/0194599815581613. Epub 2015 Apr 27.


Objective: Papillary squamous cell carcinoma has emerged as a distinct entity from the more common keratinizing squamous cell carcinoma. The basis behind this distinction relates not only to its histologic variation but also to its overall prognosis and survival. The objective of this study was to demonstrate the incidence, demographics, and long-term survival of laryngeal papillary squamous cell carcinoma (LPSCC) and how it relates to other laryngeal malignancies using a population-based database.

Study design: Analysis of a population-based tumor registry.

Methods: The United States National Cancer Institute's Surveillance, Epidemiology, and End Results registry was used to perform a retrospective analysis. Patients diagnosed with LPSCC from 1973 to 2011 were identified. Data endpoints extracted included patient demographics, incidence, and survival.

Results: Three-hundred seventy cases of LPSCC were identified, corresponding to 0.5% of all laryngeal tumors. There was a 3:1 male predilection, without a significant racial preference. Most tumors identified were localized (T1) and at stage 1. The 1-year, 5-year, and 10-year disease-specific survival (DSS) for LPSCC was 97.1%, 83.1%, and 73.9%, respectively, compared with 87.9%, 64.5%, and 50.5% for other laryngeal malignancies (P values <.0001). Surgery was associated with a higher overall DSS in both LPSCC (87.4% vs 78.8%) and other laryngeal malignancies (70% vs 59.4%) when compared with other treatment modalities.

Conclusion: This analysis of the largest sample of LPSCC demonstrates a better prognosis for this pathology compared with other laryngeal malignancies.

Keywords: SEER; demographic; disease-specific survival; incidence; laryngeal cancer; laryngeal papillary squamous cell carcinoma; papillary squamous cell carcinoma; population based analysis; relative survival; survival.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Carcinoma, Squamous Cell / epidemiology*
  • Carcinoma, Squamous Cell / mortality
  • Carcinoma, Squamous Cell / pathology*
  • Carcinoma, Squamous Cell / therapy
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Incidence
  • Infant
  • Infant, Newborn
  • Laryngeal Neoplasms / epidemiology*
  • Laryngeal Neoplasms / mortality
  • Laryngeal Neoplasms / pathology*
  • Laryngeal Neoplasms / therapy
  • Male
  • Middle Aged
  • Retrospective Studies
  • SEER Program
  • Sex Distribution
  • Survival Rate
  • United States / epidemiology
  • Young Adult