Mycology - an update Part 3: Dermatomycoses: topical and systemic therapy

J Dtsch Dermatol Ges. 2015 May;13(5):387-410; quiz 411. doi: 10.1111/ddg.12689.

Abstract

Treatment of dermatophyte infections is based on the clinical picture and mycological detection of the causative pathogen. Based on the appropriate indication, onychomycosis can be treated topically using an antimycotic nail lacquer. Atraumatic nail abrasion with 40 % urea ointment has a beneficial effect on healing. Continuous treatment of onychomycosis with terbinafine represents the most effective systemic therapy. Terbinafine or itraconazole are the safest and most effective antimycotic agents for the treatment of onychomycosis in children. For laser therapy of onychomycosis, only a few studies on clinical efficacy are available. Regarding tinea capitis, targeted species-specific therapy of dermatophytosis of the scalp is currently recommended. Terbinafine, yet also itraconazole and fluconazole, are effective in tinea capitis caused by Trichophyton species. Microsporum infections of the scalp are preferably treated with griseofulvin, alternatively with itraconazole or fluconazole. Terbinafine is less effective. Candidal intertrigo are topically treated with nystatin, but azoles or ciclopirox olamine are also suitable candidates. Systemically, fluconazole or itraconazole are used. Topical and systemic antimycotics are equivalent forms of therapy in acute vulvovaginal mycosis. Fluconazole is the drug of choice in chronic recurrent vulvovaginal mycosis caused by Candida albicans. Ketoconazole shows very good efficacy in tinea versicolor. With respect to systemic treatment of severe and widespread tinea versicolor, itraconazole is the drug of choice.

MeSH terms

  • Administration, Cutaneous
  • Anti-Inflammatory Agents / administration & dosage*
  • Antifungal Agents / administration & dosage*
  • Dermatologic Agents / administration & dosage*
  • Dermatomycoses / diagnosis*
  • Dermatomycoses / drug therapy*
  • Dose-Response Relationship, Drug
  • Drug Monitoring / methods*
  • Humans
  • Injections, Intravenous
  • Treatment Outcome

Substances

  • Anti-Inflammatory Agents
  • Antifungal Agents
  • Dermatologic Agents