Functional connectivity arises from a slow rhythmic mechanism

Proc Natl Acad Sci U S A. 2015 May 12;112(19):E2527-35. doi: 10.1073/pnas.1419837112. Epub 2015 Apr 27.

Abstract

The mechanism underlying temporal correlations among blood oxygen level-dependent signals is unclear. We used oxygen polarography to better characterize oxygen fluctuations and their correlation and to gain insight into the driving mechanism. The power spectrum of local oxygen fluctuations is inversely proportional to frequency raised to a power (1/f) raised to the beta, with an additional positive band-limited component centered at 0.06 Hz. In contrast, the power of the correlated oxygen signal is band limited from ∼ 0.01 Hz to 0.4 Hz with a peak at 0.06 Hz. These results suggest that there is a band-limited mechanism (or mechanisms) driving interregional oxygen correlation that is distinct from the mechanism(s) driving local (1/f) oxygen fluctuations. Candidates for driving interregional oxygen correlation include rhythmic or pseudo-oscillatory mechanisms.

Keywords: band-limited; criticality; oscillation; oxygen polarography; resting-state functional connectivity.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Algorithms
  • Animals
  • Arrhythmias, Cardiac
  • Brain / physiology*
  • Brain Mapping / methods*
  • Electrodes
  • Heart Rate
  • Learning
  • Macaca
  • Magnetic Resonance Imaging / methods*
  • Neural Pathways
  • Normal Distribution
  • Oscillometry
  • Oxygen / chemistry
  • Polarography
  • Rest
  • Signal Processing, Computer-Assisted

Substances

  • Oxygen