Chemical composition and biological activity of essential oils of Dracocephalum heterophyllum and Hyssopus officinalis from Western Himalaya

Nat Prod Commun. 2015 Jan;10(1):133-8.


The essential oils of two representatives of the Lamiaceae, Dracocephalum heterophyllum Benth. and Hyssopus officinalis L., are described for their antifungal, antibacterial, larvicidal and inect biting deterrent activities. Additionally, the chemical compositions of the essential oils, analyzed by simultaneous GC-MS and GC-FID, and odor descriptions are given. The main components of H. officinalis oil were pinocarvone, cis-pinocamphone, and β-pinene. Citronellol was found as the main compound of D. heterophyllum essential oil. Antibacterial testing by agar dilution assay revealed greater activity of D. heterophyllum against Staphylococcus aureus compared with H. officinalis. D. heterophyllum essential oil also showed promising antifungal activity against Colletotrichum species and was more toxic to Aedes aegypti larvae in a larvicial bioassay. Both essential oils showed high activity in the biting deterrent bioassay.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Aedes
  • Animals
  • Anti-Bacterial Agents / analysis*
  • Antifungal Agents / analysis*
  • Asia
  • Insect Repellents / analysis*
  • Lamiaceae / chemistry*
  • Microbial Sensitivity Tests
  • Oils, Volatile / chemistry*


  • Anti-Bacterial Agents
  • Antifungal Agents
  • Insect Repellents
  • Oils, Volatile