A Comparison of Survival and Recurrence Outcomes in Patients With Endometrial Cancer Undergoing Robotic Versus Open Surgery

J Minim Invasive Gynecol. Sep-Oct 2015;22(6):961-7. doi: 10.1016/j.jmig.2015.04.018. Epub 2015 Apr 25.

Abstract

Objective: To compare recurrence and survival outcomes in women who underwent either robotic or open surgical procedures to treat endometrial cancer.

Design: A retrospective chart review (Canadian Tack Force classification II-2).

Setting: A single academic institution.

Patients: A total of 936 patients who underwent surgical staging for endometrial cancer between 2001 and 2013.

Intervention: Through retrospective chart review, data were collected on patient characteristics, surgical procedures, intraoperative and postoperative complications, histopathology, adjuvant therapies, and recurrence and survival outcomes. Estimated 3-year progression-free survival and 5-year overall survival were calculated using Kaplan-Meier curves.

Main results: Of the 936 patients who underwent endometrial cancer surgery, 350 had robotic-assisted surgery and 586 had laparotomy. Both groups were comparable in terms of age, race, body mass index, and comorbid conditions. The laparotomy group had significantly more patients with grade 2-3 tumors, nonendometrioid histology, and stage III-IV disease. In a multivariate analysis, operative type was not an independent prognostic factor for intraoperative complications, but robotic surgery was associated with decreased postoperative complications and readmission rate. Median duration of follow-up was 30 months in the robotic cohort and 42 months in the laparotomy cohort. Estimated 3-year progression-free survival was 90.87% for the robotic group and 78.30% for the laparotomy group, and estimated 5-year overall survival was 89.14%for the robotic group and 79.47% for the laparotomy group. In a multivariate analysis, including stage, grade, histology, operative type, and adjuvant therapy, operative type was not an independent prognostic factor for recurrence or overall survival.

Conclusion: Compared with laparotomy, robotic staging for endometrial cancer is associated with less postoperative morbidity without compromising short-term recurrence rates or survival outcomes.

Keywords: Endometrial cancer; Laparotomy; Recurrence; Robotics; Survival.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Disease-Free Survival
  • Endometrial Neoplasms / mortality
  • Endometrial Neoplasms / surgery*
  • Female
  • Humans
  • Laparoscopy* / instrumentation
  • Laparotomy* / adverse effects
  • Laparotomy* / methods
  • Medical Records
  • Middle Aged
  • Neoplasm Recurrence, Local / prevention & control*
  • Neoplasm Staging
  • Retrospective Studies
  • Robotic Surgical Procedures* / methods