A Novel Anxiety and Affective Spectrum Disorder of Mind and Body-The ALPIM (Anxiety-Laxity-Pain-Immune-Mood) Syndrome: A Preliminary Report

J Neuropsychiatry Clin Neurosci. 2015;27(2):93-103. doi: 10.1176/appi.neuropsych.14060132.


The authors describe a spectrum disorder comprising a core anxiety (A) disorder and four domains: joint laxity (L), chronic pain syndromes (P), immune disorders (I), and mood disorders (M)-dubbed the ALPIM syndrome. This study examined 76 consecutive outpatients with an anxiety disorder plus at least one somatic condition from three domains. More than 80% of the patients had panic attacks, fibromyalgia, and major depressive episodes. Associations were found between joint laxity and bipolar III, headache with bipolar II, and bipolar II with chronic fatigue syndrome. Significant relationships were demonstrated within and between domains, validating ALPIM as a syndrome.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Affective Symptoms / complications*
  • Affective Symptoms / diagnosis
  • Aged
  • Anxiety / complications*
  • Anxiety / diagnosis
  • Cluster Analysis
  • Female
  • Humans
  • Immune System Diseases / complications*
  • Immune System Diseases / diagnosis
  • Logistic Models
  • Male
  • Middle Aged
  • Pain / complications*
  • Pain / diagnosis
  • Surveys and Questionnaires
  • Young Adult