The potential clinical impact of the tissue-based map of the human proteome

Expert Rev Proteomics. 2015 Jun;12(3):213-5. doi: 10.1586/14789450.2015.1040771. Epub 2015 Apr 30.


Since the first draft of the human genome sequence was published, several attempts have been made to map the human proteome, the functional representation of the genome. One such initiative is the Human Protein Atlas project, which recently released a tissue-based map of the human proteome. The Human Protein Atlas is based on the combination of transcriptomics and antibody-based proteomics for mapping the human proteome down to the single cell level. The comprehensive publicly available database contains more than 13 million unique immunohistochemistry images and provides an excellent resource for exploration and investigation of future drug targets and disease biomarkers.

Keywords: immunohistochemistry; proteome; proteomics; tissue microarrays; transcriptomics.

Publication types

  • Editorial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies / metabolism
  • Clinical Medicine / trends
  • Human Genome Project*
  • Humans
  • Organ Specificity
  • Proteome / metabolism*
  • Proteomics
  • Transcriptome*


  • Antibodies
  • Proteome