E-cadherin junctions as active mechanical integrators in tissue dynamics

Nat Cell Biol. 2015 May;17(5):533-9. doi: 10.1038/ncb3136.


During epithelial morphogenesis, E-cadherin adhesive junctions play an important part in mechanically coupling the contractile cortices of cells together, thereby distributing the stresses that drive cell rearrangements at both local and tissue levels. Here we discuss the concept that cellular contractility and E-cadherin-based adhesion are functionally integrated by biomechanical feedback pathways that operate on molecular, cellular and tissue scales.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Actomyosin / metabolism
  • Animals
  • Antigens, CD
  • Biomechanical Phenomena
  • Cadherins / metabolism*
  • Cell Adhesion*
  • Cell Communication*
  • Cell Shape
  • Cytoskeleton / metabolism
  • Epithelial Cells / metabolism*
  • Humans
  • Intercellular Junctions / metabolism*
  • Mechanotransduction, Cellular*
  • Morphogenesis
  • Stress, Mechanical


  • Antigens, CD
  • CDH1 protein, human
  • Cadherins
  • Actomyosin