Ameloblastoma: a clinical review and trends in management

Eur Arch Otorhinolaryngol. 2016 Jul;273(7):1649-61. doi: 10.1007/s00405-015-3631-8. Epub 2015 Apr 30.


Ameloblastoma is a rare odontogenic neoplasm of the mandible and maxilla, with multiple histologic variants, and high recurrence rates if improperly treated. The current mainstay of treatment is wide local excision with appropriate margins and immediate reconstruction. Here we review the ameloblastoma literature, using the available evidence to highlight the change in management over the past several decades. In addition, we explore the recent molecular characterization of these tumors which may point towards new potential avenues of personalized treatment.

Keywords: Ameloblastoma; BRAF; Clinical review; Genomics; Head and neck surgery; Personalized medicine; SHH.

Publication types

  • Review

MeSH terms

  • Ameloblastoma* / pathology
  • Ameloblastoma* / physiopathology
  • Ameloblastoma* / surgery
  • Disease Management
  • Humans
  • Jaw Neoplasms* / pathology
  • Jaw Neoplasms* / physiopathology
  • Jaw Neoplasms* / surgery
  • Mandible / diagnostic imaging
  • Mandible / pathology
  • Mandibular Neoplasms / pathology
  • Maxilla / diagnostic imaging
  • Maxilla / pathology
  • Oral Surgical Procedures / methods*
  • Plastic Surgery Procedures / methods*
  • Prognosis