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. 2015 Apr 29;5(4):e007688.
doi: 10.1136/bmjopen-2015-007688.

Electronic Nicotine Delivery Devices, and Their Impact on Health and Patterns of Tobacco Use: A Systematic Review Protocol

Free PMC article

Electronic Nicotine Delivery Devices, and Their Impact on Health and Patterns of Tobacco Use: A Systematic Review Protocol

Allison M Glasser et al. BMJ Open. .
Free PMC article


Introduction: E-cigarettes or electronic nicotine delivery systems (ENDS) have recently attracted considerable attention. Among some individuals there is strong debate and a polarisation of views about the public health benefits versus harms of ENDS. With little regulation, the ENDS market is evolving, and new products are introduced and marketed constantly. Rapid developments in manufacturing, marketing and consumer domains related to ENDS will warrant frequent re-evaluation, based on the state of the evolving science. The purpose of this article is to describe a protocol for an ongoing comprehensive review of the published scientific literature on ENDS.

Methods and analysis: We will undertake a systematic review of published empirical research literature on ENDS using the National Library of Medicine's PubMed electronic database to search for relevant articles. Data from included studies will be extracted into a standardised form, tables with study details and key outcomes for each article will be created, and studies will be synthesised qualitatively.

Ethics and dissemination: This review synthesises published literature and presents no primary data. Therefore, no ethical approval is required for this study. Subsequent papers will provide greater detail on results, within select categories, that represent gaps in the literature base.


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