Use of Antiepileptic Drugs in Patients with Chronic Kidney Disease and End Stage Renal Disease

Semin Dial. 2015 Jul-Aug;28(4):404-12. doi: 10.1111/sdi.12385. Epub 2015 May 1.


Epilepsy is a disorder with an approximate worldwide prevalence of 1%. Due to complexities of metabolism, protein-binding, renal elimination, and other pharmacokinetic parameters, the dosing of antiepileptic drugs (AEDs) in patients with chronic kidney disease (CKD) or end stage renal disease (ESRD) deserves special attention. This is a review of the most commonly prescribed AEDs with special focus on their indication, pharmacokinetics, and unique considerations for use in patients with CKD and ESRD. A review of their renal toxicities is also included.

Publication types

  • Review

MeSH terms

  • Anticonvulsants / therapeutic use*
  • Epilepsy / complications*
  • Epilepsy / drug therapy*
  • Humans
  • Kidney Failure, Chronic / complications
  • Renal Insufficiency, Chronic / complications*


  • Anticonvulsants