Acute responses to opioidergic blockade as a biomarker of hedonic eating among obese women enrolled in a mindfulness-based weight loss intervention trial

Appetite. 2015 Aug;91:311-320. doi: 10.1016/j.appet.2015.04.062. Epub 2015 Apr 27.


There are currently no commonly used or easily accessible 'biomarkers' of hedonic eating. Physiologic responses to acute opioidergic blockade, indexed by cortisol changes and nausea, may represent indirect functional measures of opioid-mediated hedonic eating drive and predict weight loss following a mindfulness-based intervention for stress eating. In the current study, we tested whether cortisol and nausea responses induced by oral ingestion of an opioidergic antagonist (naltrexone) correlated with weight and self-report measures of hedonic eating and predicted changes in these measures following a mindfulness-based weight loss intervention. Obese women (N = 88; age = 46.7 ± 13.2 years; BMI = 35.8 ± 3.8) elected to complete an optional sub-study prior to a 5.5-month weight loss intervention with or without mindfulness training. On two separate days, participants ingested naltrexone and placebo pills, collected saliva samples, and reported nausea levels. Supporting previous findings, naltrexone-induced cortisol increases were associated with greater hedonic eating (greater food addiction symptoms and reward-driven eating) and less mindful eating. Among participants with larger cortisol increases (+1 SD above mean), mindfulness participants (relative to control participants) reported greater reductions in food addiction symptoms, b = -0.95, SE(b) = 0.40, 95% CI [-1.74, -0.15], p = .021. Naltrexone-induced nausea was marginally associated with reward-based eating. Among participants who endorsed naltrexone-induced nausea (n = 38), mindfulness participants (relative to control participants) reported greater reductions in food addiction symptoms, b = -1.00, 95% CI [-1.85, -0.77], p = .024, and trended toward reduced reward-based eating, binge eating, and weight, post-intervention. Single assessments of naltrexone-induced cortisol increases and nausea responses may be useful time- and cost-effective biological markers to identify obese individuals with greater opioid-mediated hedonic eating drive who may benefit from weight loss interventions with adjuvant mindfulness training that targets hedonic eating.

Keywords: Cortisol; Hedonic eating; Mindfulness intervention; Naltrexone; Nausea.

Publication types

  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Behavior, Addictive / complications
  • Behavior, Addictive / psychology
  • Binge-Eating Disorder / prevention & control
  • Body Mass Index
  • Body Weight
  • Bulimia / prevention & control
  • Eating / psychology*
  • Emotions
  • Female
  • Humans
  • Hydrocortisone / blood*
  • Middle Aged
  • Mindfulness*
  • Motivation
  • Naltrexone / adverse effects
  • Naltrexone / therapeutic use*
  • Narcotic Antagonists / adverse effects
  • Narcotic Antagonists / therapeutic use*
  • Nausea / etiology*
  • Obesity / drug therapy*
  • Obesity / metabolism
  • Obesity / psychology
  • Opioid Peptides / metabolism
  • Receptors, Opioid / metabolism
  • Reward
  • Stress, Psychological
  • Weight Reduction Programs / methods


  • Narcotic Antagonists
  • Opioid Peptides
  • Receptors, Opioid
  • Naltrexone
  • Hydrocortisone