Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 35 (10), 2028-36

FELLOW EYE CHANGES IN PATIENTS WITH NONISCHEMIC CENTRAL RETINAL VEIN OCCLUSION: Assessment of Perfused Foveal Microvascular Density and Identification of Nonperfused Capillaries

Affiliations

FELLOW EYE CHANGES IN PATIENTS WITH NONISCHEMIC CENTRAL RETINAL VEIN OCCLUSION: Assessment of Perfused Foveal Microvascular Density and Identification of Nonperfused Capillaries

Alexander Pinhas et al. Retina.

Abstract

Purpose: Eyes fellow to nonischemic central retinal vein occlusion (CRVO) were examined for abnormalities, which might explain their increased risk for future occlusion, using adaptive optics scanning light ophthalmoscope fluorescein angiography.

Methods: Adaptive optics scanning light ophthalmoscope fluorescein angiography foveal microvascular densities were calculated. Nonperfused capillaries adjacent to the foveal avascular zone were identified. Spectral domain optical coherence tomography, ultrawide field fluorescein angiographies, and microperimetry were also performed.

Results: Ten fellow eyes of nine nonischemic CRVO and 1 nonischemic hemi-CRVO subjects and four affected eyes of three nonischemic CRVO and one nonischemic hemi-CRVO subjects were imaged. Ninety percent of fellow eyes and 100% of affected eyes demonstrated at least 1 nonperfused capillary compared with 31% of healthy eyes. Fellow eye microvascular density (35 ± 3.6 mm(-1)) was significantly higher than that of affected eyes (25 ± 5.2 mm(-1)) and significantly lower than that of healthy eyes (42 ± 4.2 mm(-1)). Compared with healthy controls, spectral domain optical coherence tomography thicknesses showed no significant difference, whereas microperimetry and 2/9 ultrawide field fluorescein angiography revealed abnormalities in fellow eyes.

Conclusion: Fellow eye changes detectable on adaptive optics scanning light ophthalmoscope fluorescein angiography reflect subclinical pathology difficult to detect using conventional imaging technologies. These changes may help elucidate the pathogenesis of nonischemic CRVO and help identify eyes at increased risk of future occlusion.

Conflict of interest statement

A. Dubra: US Patent No: 8,226,236: Code P (Patent). R. B. Rosen: Clarity: Code C (Consultant); Opticology: Code C (Consultant); OD–OS: Code C (Consultant); Allergan: Code C (Consultant); Carl Zeiss Meditec: Code C (Consultant); Optovue: Code C (Consultant); Advanced Cellular Technologies: Code C (Consultant). The other authors do not have any conflicting interests to disclose.

Figures

Fig. 1
Fig. 1
A. Fluorescein angiography perfusion map of RR_0289 fellow eye (left eye), showing foveal avascular zone and surrounding capillaries. B. Corresponding IR structural map. Arrows indicate non-perfused capillaries.
Fig. 2
Fig. 2
A. Fluorescein angiography (FA) perfusion map of RR_0289 fellow eye (left eye). B. Corresponding skeletonized FA perfusion map with (C) octant and annulus grid overlay. D. Colorized density contour map. S, superior; SN, superior nasal; N, nasal; IN, inferior nasal; I, inferior; IT, inferior temporal; T, temporal; ST, superior temporal.
Fig. 3
Fig. 3
Examples of fellow eye angiopathy discovered on ultrawide field fluorescein angiography. A. RR_0235 left eye showed leakage at a terminal branch of the superotemporal arcade. B. RR_0289 left eye showed a few central and peripheral microaneurysms (arrows).
Fig. 4
Fig. 4
A. Scatter plot of microvascular density values of fellow eyes (n = 10), compared with healthy (n = 16) and affected eyes (n = 4). Microvascular density values are presented per eye as averages of annuli 300–800. Black bars indicate group averages. B. An annulus comparison of microvascular densities of the 3 groups. Error bars represent SD. Asterisks indicate significant differences (unpaired t-test with P < 0.05) between healthy and fellow eyes (blue asterisks) and affected and fellow eyes (green asterisks) in microvascular densities at a given annulus.
Fig. 5
Fig. 5
RR0182-affected eye (nonischemic central retinal vein occlusion in the right eye) and fellow eye (left eye) compared with a healthy control eye, with fluorescein angiography (FA) perfusion maps and corresponding colorized density contour maps. Subject age, sex, eye imaged, and perfused foveal microvascular density (mean of annuli 300–800) appear in the lower left corner of respective FA perfusion maps.
Fig. 6
Fig. 6
RR0235-affected eye (nonischemic superior hemiretinal vein occlusion in the right eye) and fellow eye (left eye) compared with a healthy control eye, with fluorescein angiography (FA) perfusion maps and corresponding colorized density contour maps. Subject age, sex, eye imaged, and perfused foveal microvascular density (mean of annuli 300–800) appear in the lower left corner of respective FA perfusion maps.

Similar articles

See all similar articles

Cited by 8 PubMed Central articles

See all "Cited by" articles

Publication types

MeSH terms

Feedback