The study of DNA sequences by their sequences of twist angles

J Theor Biol. 1989 Jun 22;138(4):457-65. doi: 10.1016/s0022-5193(89)80044-x.


To study the properties of DNA sequences we have transformed the sequences of bases into the sequences of twist angles along the chain of DNA double helix by using the Dickerson sum function. The Fourier transform and the auto-correlation function of the twist angles sequences have been used to study the periodicity and randomness of the original DNA sequences. Basing on the correlation coefficient, a "distance" between two DNA fragments has been defined and used to compare some realistic DNA sequences. It is hoped that the techniques developed here could be used to analyze more realistic DNA sequences.

MeSH terms

  • Base Sequence*
  • DNA / analysis*
  • Mathematics
  • Periodicity


  • DNA