Five new cycloartane triterpenoids from Beesia calthifolia

Fitoterapia. 2015 Jun:103:283-8. doi: 10.1016/j.fitote.2015.04.017. Epub 2015 Apr 30.

Abstract

Phytochemical study on rhizomes of Beesia calthifolia resulted in the isolation of five new (1-5) and three known (6-8) cycloartane triterpenoids possessing a hemiketal or ketal group at C-24 from the EtOAc fraction of 95% ethanol extract. Their structures were determined by spectroscopic and chemical methods, especially HRMS and 2D NMR techniques. Compounds 3 and 4 showed potential hepatoprotective activities against D-galactosamine induced human hepatic L02 cell damage.

Keywords: 2D NMR; Beesia calthifolia; Cycloartane triterpenoid; Hepatoprotective activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line
  • Galactosamine / adverse effects
  • Hepatocytes / drug effects*
  • Humans
  • Molecular Structure
  • Ranunculaceae / chemistry*
  • Rhizome / chemistry
  • Triterpenes / chemistry*

Substances

  • Triterpenes
  • cycloartane
  • Galactosamine