ADP-ribosyltransferases and poly ADP-ribosylation

Curr Protein Pept Sci. 2015;16(6):491-501. doi: 10.2174/1389203716666150504122435.


Protein ADP-ribosylation is an important posttranslational modification that plays versatile roles in multiple biological processes. ADP-ribosylation is catalyzed by a group of enzymes known as ADP-ribosyltransferases (ARTs). Using nicotinamide adenine dinucleotide (NAD(+)) as the donor, ARTs covalently link single or multiple ADP-ribose moieties from NAD(+) to the substrates, forming mono ADP-ribosylation or poly ADP-ribosylation (PARylation). Novel functions of ARTs and ADPribosylation have been revealed over the past few years. Here we summarize the current knowledge on ARTs and PARylation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • ADP Ribose Transferases / chemistry
  • ADP Ribose Transferases / genetics
  • ADP Ribose Transferases / metabolism*
  • Animals
  • Catalysis
  • Chromatin Assembly and Disassembly
  • DNA Damage
  • Humans
  • NAD / metabolism
  • Poly(ADP-ribose) Polymerases / chemistry
  • Poly(ADP-ribose) Polymerases / genetics
  • Poly(ADP-ribose) Polymerases / metabolism
  • Protein Binding
  • Protein Interaction Domains and Motifs
  • Protein Processing, Post-Translational*


  • NAD
  • ADP Ribose Transferases
  • Poly(ADP-ribose) Polymerases