Emerging properties of nuclear RNP biogenesis and export

Curr Opin Cell Biol. 2015 Jun;34:46-53. doi: 10.1016/j.ceb.2015.04.007. Epub 2015 May 15.


RNA biology has recently seen an explosion of data due to advances in RNA sequencing, proteomic, and RNA imaging technologies. In this review, we highlight progress that has been made using these approaches in the area of nuclear RNP biogenesis and export. Excitingly, the ability to collect quantitative data at the 'omics' scale combined with measurements of transcription, decay, and transport kinetics is providing the information needed to address RNP biogenesis at a systems level. We believe this to be a necessary and critical next step that will lead to a better understanding of how RNP quality, diversity, and fate emerge from a defined set of nuclear RNP assembly and maturation steps.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • Protein Transport
  • RNA / genetics
  • RNA-Binding Proteins / metabolism
  • Ribonucleoproteins / metabolism*


  • RNA-Binding Proteins
  • Ribonucleoproteins
  • RNA