Abstract
A chiral N-heterocyclic carbene (NHC)-catalyzed [3 + 3] cycloaddition reaction of imines and oxindole-derived enals was developed for rapid access to spirocylic oxindoles. In most cases, the desired spirocylic oxindole products were obtained in high yields and excellent enantioselectivities with less than 1 h of reaction time.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aldehydes / chemistry*
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Catalysis
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Cycloaddition Reaction
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Heterocyclic Compounds / chemistry*
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Imines / chemistry*
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Indoles / chemical synthesis*
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Indoles / chemistry*
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Methane / analogs & derivatives*
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Methane / chemistry
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Molecular Structure
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Oxindoles
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Spiro Compounds / chemistry*
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Stereoisomerism
Substances
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Aldehydes
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Heterocyclic Compounds
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Imines
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Indoles
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Oxindoles
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Spiro Compounds
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2-oxindole
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carbene
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Methane