Thin-membrane nephropathy--a common cause of glomerular haematuria

Med J Aust. 1989 Dec 4-18;151(11-12):638-42. doi: 10.5694/j.1326-5377.1989.tb139637.x.

Abstract

Thin-membrane nephropathy recently has been described as a cause of glomerular haematuria. The prognosis of the condition is unclear but it generally is considered to be benign. In a series of 92 patients with glomerular haematuria, thin-membrane nephropathy was found to be a common cause, occurring in 26 (28%) patients. Sixteen patients were women. The mean age was 42 years. Four patients had a family history of renal disease or haematuria and no patient was deaf. Haematuria had been present from six days to 30 years. Loin pain occurred in 31% of patients. Hypertension was not a feature and mild renal impairment was present in one case only, while a further three cases showed proteinuria at a level of greater than 500 mg of protein per day. Glomerular basement membranes in patients with thin-membrane nephropathy gave a mean (+/- standard deviation) width of 319 + 37 nm which was significantly (P less than 0.002) less than the control value of 394 +/- 61 nm. On the basis of clinical features and serological parameters, thin-membrane nephropathy could not be separated from other renal causes of haematuria but required careful electronmicroscopic examination of renal biopsy material to establish the diagnosis. Limited follow-up has confirmed the good prognosis of the condition.

MeSH terms

  • Adult
  • Basement Membrane / pathology
  • Female
  • Hematuria / etiology*
  • Humans
  • Kidney Diseases / complications*
  • Kidney Diseases / pathology
  • Kidney Glomerulus / ultrastructure
  • Microscopy, Electron
  • Middle Aged
  • Prospective Studies
  • Retrospective Studies