Familial hypercholesterolemia

Cardiol Clin. 2015 May;33(2):169-79. doi: 10.1016/j.ccl.2015.01.001.

Abstract

Familial hypercholesterolemia is a common, inherited disorder of cholesterol metabolism that leads to early cardiovascular morbidity and mortality. It is underdiagnosed and undertreated. Statins, ezetimibe, bile acid sequestrants, niacin, lomitapide, mipomersen, and low-density lipoprotein (LDL) apheresis are treatments that can lower LDL cholesterol levels. Early treatment can lead to substantial reduction of cardiovascular events and death in patients with familial hypercholesterolemia. It is important to increase awareness of this disorder in physicians and patients to reduce the burden of this disorder.

Keywords: Bile acid sequestrants; Ezetimibe; Familial hypercholesterolemia; LDL apheresis; Lomitapide; Mipomersen; Statins.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Anticholesteremic Agents / therapeutic use*
  • Blood Component Removal / methods*
  • Genetic Predisposition to Disease*
  • Global Health
  • Humans
  • Hyperlipoproteinemia Type II* / blood
  • Hyperlipoproteinemia Type II* / epidemiology
  • Hyperlipoproteinemia Type II* / therapy
  • Lipoproteins / blood*
  • Prevalence

Substances

  • Anticholesteremic Agents
  • Lipoproteins