Altered germinal center reaction and abnormal B cell peripheral maturation in PI3KR1-mutated patients presenting with HIGM-like phenotype

doi:10.1016/j.clim.2015.04.014

. 2015 Jul;159(1):33-6.

doi: 10.1016/j.clim.2015.04.014. Epub 2015 May 1.

Altered germinal center reaction and abnormal B cell peripheral maturation in PI3KR1-mutated patients presenting with HIGM-like phenotype

Vassilios Lougaris¹, Flavio Faletra², Gaetana Lanzi³, Diego Vozzi², Annalisa Marcuzzi², Erica Valencic², Elisa Piscianz², AnnaMonica Bianco², Martina Girardelli², Manuela Baronio⁴, Claudia Loganes², Anders Fasth⁵, Filippo Salvini⁶, Antonino Trizzino⁷, Daniele Moratto³, Fabio Facchetti⁸, Silvia Giliani³, Alessandro Plebani⁴, Alberto Tommasini²

Affiliations

¹ Pediatrics Clinic and Institute for Molecular Medicine A. Nocivelli, Department of Clinical and Experimental Sciences, University of Brescia, Spedali Civili di Brescia, Italy. Electronic address: vlougarisbs@yahoo.com.
² Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy.
³ Institute for Molecular Medicine A.Nocivelli and Department of Pathology, Laboratory of Genetic Disorders of Childhood, Department of Molecular and Translational Medicine, University of Brescia, Spedali Civili di Brescia, Italy.
⁴ Pediatrics Clinic and Institute for Molecular Medicine A. Nocivelli, Department of Clinical and Experimental Sciences, University of Brescia, Spedali Civili di Brescia, Italy.
⁵ Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
⁶ Pediatric Department, San Paolo Hospital, University of Milan, Italy.
⁷ Department of Pediatric Oncology and Hematology, ARNAS CIVICO, Palermo, Italy.
⁸ Pathology Unit, Department of Molecular and Translational Medicine, University of Brescia, Italy.

PMID: 25939554
DOI: 10.1016/j.clim.2015.04.014

Altered germinal center reaction and abnormal B cell peripheral maturation in PI3KR1-mutated patients presenting with HIGM-like phenotype

Vassilios Lougaris et al. Clin Immunol. 2015 Jul.

. 2015 Jul;159(1):33-6.

doi: 10.1016/j.clim.2015.04.014. Epub 2015 May 1.

Authors

Affiliations

¹ Pediatrics Clinic and Institute for Molecular Medicine A. Nocivelli, Department of Clinical and Experimental Sciences, University of Brescia, Spedali Civili di Brescia, Italy. Electronic address: vlougarisbs@yahoo.com.
² Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy.
³ Institute for Molecular Medicine A.Nocivelli and Department of Pathology, Laboratory of Genetic Disorders of Childhood, Department of Molecular and Translational Medicine, University of Brescia, Spedali Civili di Brescia, Italy.
⁴ Pediatrics Clinic and Institute for Molecular Medicine A. Nocivelli, Department of Clinical and Experimental Sciences, University of Brescia, Spedali Civili di Brescia, Italy.
⁵ Department of Pediatrics, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
⁶ Pediatric Department, San Paolo Hospital, University of Milan, Italy.
⁷ Department of Pediatric Oncology and Hematology, ARNAS CIVICO, Palermo, Italy.
⁸ Pathology Unit, Department of Molecular and Translational Medicine, University of Brescia, Italy.

PMID: 25939554
DOI: 10.1016/j.clim.2015.04.014

No abstract available

Keywords: B cells; Germinal Center (GC) reaction; Hyper-IgM syndrome; PIK3R1.

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Altered germinal center reaction and abnormal B cell peripheral maturation in PI3KR1-mutated patients presenting with HIGM-like phenotype

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Altered germinal center reaction and abnormal B cell peripheral maturation in PI3KR1-mutated patients presenting with HIGM-like phenotype

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