Efficient intracellular delivery and improved biocompatibility of colloidal silver nanoparticles towards intracellular SERS immuno-sensing

Analyst. 2015 Jun 21;140(12):3929-34. doi: 10.1039/c5an00435g. Epub 2015 May 5.


High throughput intracellular delivery strategies, electroporation, passive and TATHA2 facilitated diffusion of colloidal silver nanoparticles (AgNPs) are investigated for cellular toxicity and uptake using state-of-art analytical techniques. The TATHA2 facilitated approach efficiently delivered high payload with no toxicity, pre-requisites for intracellular applications of plasmonic metal nanoparticles (PMNPs) in sensing and therapeutics.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Biocompatible Materials / chemistry
  • Biocompatible Materials / metabolism
  • Biological Transport
  • Biosensing Techniques*
  • Electroporation
  • Immunoassay*
  • Intracellular Space / metabolism*
  • Nanoparticles*
  • Peptides / chemistry*
  • Silver / chemistry*
  • Silver / metabolism*


  • Biocompatible Materials
  • Peptides
  • colloidal silver
  • Silver