Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Jul;58(7):1464-73.
doi: 10.1007/s00125-015-3580-1. Epub 2015 May 6.

Maternal Overweight and Obesity Are Associated With Increased Risk of Type 1 Diabetes in Offspring of Parents Without Diabetes Regardless of Ethnicity

Affiliations

Maternal Overweight and Obesity Are Associated With Increased Risk of Type 1 Diabetes in Offspring of Parents Without Diabetes Regardless of Ethnicity

Hozan I Hussen et al. Diabetologia. .

Abstract

Aims/hypothesis: The incidence of type 1 diabetes in children is increasing in Sweden, as is the prevalence of maternal overweight/obesity. Therefore, the aim of this study was to investigate if maternal overweight/obesity increases the risk of type 1 diabetes in offspring of parents with and without diabetes, and of different ethnicities.

Methods: The study cohort comprised 1,263,358 children, born in Sweden between 1992 and 2004. Children were followed from birth until diagnosis of type 1 diabetes, emigration, death or end of follow-up in 2009, whichever occurred first. First trimester maternal BMI was calculated (kg/m(2)). Poisson regression was used to calculate incidence rate ratios (IRRs) with 95% CI for type 1 diabetes in the offspring.

Results: The risk of type 1 diabetes was increased in offspring of parents with any type of diabetes regardless of parental ethnicity. High first trimester maternal BMI was associated with increased risk of type 1 diabetes only in offspring of parents without diabetes (IRR 1.33 [95% CI 1.20, 1.48]).

Conclusions/interpretation: Increasing incidence of type 1 diabetes in children with non-diabetic parents may partly be explained by increasing prevalence of maternal overweight/obesity.

Comment in

Similar articles

See all similar articles

Cited by 14 articles

See all "Cited by" articles

References

    1. Acta Paediatr. 1996 Jul;85(7):843-8 - PubMed
    1. Diabetes Care. 1999 Jun;22(6):928-32 - PubMed
    1. J Reprod Med. 2007 Oct;52(10):907-11 - PubMed
    1. BMJ Open. 2013 Oct 31;3(10):e003418 - PubMed
    1. Diabetologia. 2005 Jun;48(6):1114-7 - PubMed

Publication types

MeSH terms

LinkOut - more resources

Feedback