Lessons From Immunology: IL4R Directly Promotes Mammary Tumor Metastasis

Oncoimmunology. 2014 Dec 13;3(9):e955373. doi: 10.4161/21624011.2014.955373. eCollection 2014 Oct.

Abstract

Interleukin-4 (IL4), a Th2 cytokine, signals through IL4 receptors (IL4Rs) to regulate increased lymphocyte proliferation and survival. We have recently discovered that IL4 also promotes these phenotypes in mammary cancer cells expressing IL4Rs to enhance their metastatic ability. Targeting IL4/IL4R signaling on cancer cells themselves may limit metastatic disease.

Keywords: Akt; Erk; breast cancer; liver metastasis; mTOR; proliferation; survival.