Early chronic obstructive pulmonary disease: definition, assessment, and prevention

Lancet. 2015 May 2;385(9979):1778-1788. doi: 10.1016/S0140-6736(15)60647-X.


Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. COPD, however, is a heterogeneous collection of diseases with differing causes, pathogenic mechanisms, and physiological effects. Therefore a comprehensive approach to COPD prevention will need to address the complexity of COPD. Advances in the understanding of the natural history of COPD and the development of strategies to assess COPD in its early stages make prevention a reasonable, if ambitious, goal.

Publication types

  • Review

MeSH terms

  • Albuterol / analogs & derivatives
  • Albuterol / therapeutic use
  • Androstadienes / therapeutic use
  • Anti-Inflammatory Agents / therapeutic use*
  • Bronchodilator Agents / therapeutic use*
  • Disease Progression
  • Drug Combinations
  • Early Diagnosis
  • Early Medical Intervention*
  • Exercise Test
  • Fluticasone-Salmeterol Drug Combination
  • Forced Expiratory Volume
  • Humans
  • Pulmonary Disease, Chronic Obstructive / diagnosis*
  • Pulmonary Disease, Chronic Obstructive / prevention & control
  • Respiratory Function Tests
  • Severity of Illness Index
  • Smoking Cessation*


  • Androstadienes
  • Anti-Inflammatory Agents
  • Bronchodilator Agents
  • Drug Combinations
  • Fluticasone-Salmeterol Drug Combination
  • Albuterol