Hyaluronic acid in knee osteoarthritis: preliminary results using a four months administration schedule

Int J Rheum Dis. 2017 Feb;20(2):199-202. doi: 10.1111/1756-185X.12572. Epub 2015 May 5.

Abstract

Aim: To evaluate the therapeutic trajectory of intra-articular injections of hyaluronic acid at high concentration (2%) performed at 4-month intervals.

Methods: Subjects with knee osteoarthritis received, after a weekly injection of 32 mg/2 mL hyaluronic acid for 3 weeks, a single injection of 50 mg/2.5 mL hyaluronic acid (not cross-linked, molecular weight 800-1200 kDa) at 4-month interval (4, 8 and 12 months). Clinical assessment (visual analogic scale [VAS] for pain at rest and during activities, Lequesne Index [LI], Knee Injury and Osteoarthritis Outcome Score (KOOS), and monthly non-steroidal anti-inflammatory drug consumption) was performed at baseline, and after 1, 4, 6, 8, 12 and 14 months.

Results: In the 15 knees treated, pain decreased (baseline vs. 14 months: VAS at rest, 3.7 ± 1.7 vs. 1 ± 0.7 [P < 0.000]; VAS activities, 6.2 ± 1.7 vs. 2.6 ± 1.3 [P < 0.000]) and function improved (baseline vs. 14 months: KOOS, 51.9 ± 15.3 vs. 70.2 ± 13.7 [P < 0.000]; LI, 10 ± 3.8 vs. 5.4 ± 2.4 [P < 0.000]) significantly.

Conclusions: This schedule provides persistent positive results in terms of reduced pain and improved function, optimizing the protective properties of the hyaluronic acid used.

Keywords: hyaluronic acid; knee osteoarthritis; therapeutic trajectory; viscosupplementation.

Publication types

  • Observational Study

MeSH terms

  • Aged
  • Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
  • Arthralgia / diagnosis
  • Arthralgia / drug therapy*
  • Arthralgia / physiopathology
  • Drug Administration Schedule
  • Female
  • Humans
  • Hyaluronic Acid / administration & dosage*
  • Hyaluronic Acid / adverse effects
  • Injections, Intra-Articular
  • Knee Joint / drug effects*
  • Knee Joint / physiopathology
  • Male
  • Middle Aged
  • Osteoarthritis, Knee / diagnosis
  • Osteoarthritis, Knee / drug therapy*
  • Osteoarthritis, Knee / physiopathology
  • Pain Measurement
  • Preliminary Data
  • Recovery of Function
  • Time Factors
  • Treatment Outcome
  • Viscosupplementation* / adverse effects
  • Viscosupplements / administration & dosage*
  • Viscosupplements / adverse effects

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Viscosupplements
  • Hyaluronic Acid