Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015;2015:234952.
doi: 10.1155/2015/234952. Epub 2015 Apr 6.

Sleep Deprivation and Oxidative Stress in Animal Models: A Systematic Review

Free PMC article

Sleep Deprivation and Oxidative Stress in Animal Models: A Systematic Review

Gabriel Villafuerte et al. Oxid Med Cell Longev. .
Free PMC article


Because the function and mechanisms of sleep are partially clear, here we applied a meta-analysis to address the issue whether sleep function includes antioxidative properties in mice and rats. Given the expansion of the knowledge in the sleep field, it is indeed ambitious to describe all mammals, or other animals, in which sleep shows an antioxidant function. However, in this paper we reviewed the current understanding from basic studies in two species to drive the hypothesis that sleep is a dynamic-resting state with antioxidative properties. We performed a systematic review of articles cited in Medline, Scopus, and Web of Science until March 2015 using the following search terms: Sleep or sleep deprivation and oxidative stress, lipid peroxidation, glutathione, nitric oxide, catalase or superoxide dismutase. We found a total of 266 studies. After inclusion and exclusion criteria, 44 articles were included, which are presented and discussed in this study. The complex relationship between sleep duration and oxidative stress is discussed. Further studies should consider molecular and genetic approaches to determine whether disrupted sleep promotes oxidative stress.


Figure 1
Figure 1
Flowchart for articles selection.

Similar articles

See all similar articles

Cited by 30 articles

See all "Cited by" articles


    1. Arias-Carrión O., Huitrón-Reséndiz S., Arankowsky-Sandoval G., Murillo-Rodríguez E. Biochemical modulation of the sleep-wake cycle: endogenous sleep-inducing factors. Journal of Neuroscience Research. 2011;89(8):1143–1149. doi: 10.1002/jnr.22666. - DOI - PubMed
    1. Murillo-Rodríguez E., Arias-Carrión O., Sanguino-Rodríguez K., González-Arias M., Haro R. Mechanisms of sleep-wake cycle modulation. CNS and Neurological Disorders—Drug Targets. 2009;8(4):245–253. doi: 10.2174/187152709788921654. - DOI - PubMed
    1. Murillo-Rodriguez E., Arias-Carrion O., Zavala-Garcia A., et al. Basic sleep mechanisms: an integrative review. Central Nervous System Agents in Medicinal Chemistry. 2012;12(1):38–54. - PubMed
    1. Siegel J. M. Clues to the functions of mammalian sleep. Nature. 2005;437(7063):1264–1271. doi: 10.1038/nature04285. - DOI - PubMed
    1. Rechtschaffen A. Current perspectives on the function of sleep. Perspectives in Biology and Medicine. 1998;41(3):359–390. doi: 10.1353/pbm.1998.0051. - DOI - PubMed