Sleep deprivation and oxidative stress in animal models: a systematic review

Oxid Med Cell Longev. 2015;2015:234952. doi: 10.1155/2015/234952. Epub 2015 Apr 6.


Because the function and mechanisms of sleep are partially clear, here we applied a meta-analysis to address the issue whether sleep function includes antioxidative properties in mice and rats. Given the expansion of the knowledge in the sleep field, it is indeed ambitious to describe all mammals, or other animals, in which sleep shows an antioxidant function. However, in this paper we reviewed the current understanding from basic studies in two species to drive the hypothesis that sleep is a dynamic-resting state with antioxidative properties. We performed a systematic review of articles cited in Medline, Scopus, and Web of Science until March 2015 using the following search terms: Sleep or sleep deprivation and oxidative stress, lipid peroxidation, glutathione, nitric oxide, catalase or superoxide dismutase. We found a total of 266 studies. After inclusion and exclusion criteria, 44 articles were included, which are presented and discussed in this study. The complex relationship between sleep duration and oxidative stress is discussed. Further studies should consider molecular and genetic approaches to determine whether disrupted sleep promotes oxidative stress.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't
  • Review
  • Systematic Review

MeSH terms

  • Animals
  • Databases, Factual
  • Glutathione / metabolism
  • Lipid Peroxidation
  • Models, Animal
  • Nitric Oxide / metabolism
  • Oxidative Stress*
  • Oxidoreductases / metabolism
  • Reactive Oxygen Species / metabolism
  • Sleep Deprivation / metabolism
  • Sleep Deprivation / pathology*


  • Reactive Oxygen Species
  • Nitric Oxide
  • Oxidoreductases
  • Glutathione