[Impact of tetrapeptide pancragen on endocrine function of the pancreas in old monkeys]

Adv Gerontol. 2014;27(4):662-7.
[Article in Russian]


Significant increase of the elderly in the demographic structure of a modern society is one of the main reasons for increase in the number of patients with diabetes type 2 and impaired glucose tolerance. The purpose of this research was to study impact of Pancragen (tetrapeptide Lys-Glu-Asp-Trp) on endocrine function of the pancreas of non-human primates, female rhesus monkeys, and to elucidate the possibil- ity of its use for correction age-related dysfunction of pancreatic islet apparatus. In old animals after the glucose administration (standard dose) in control period, a reduced glucose "disappearance" rate and a higher values of insulin and C-peptide peaks (5 and 15 min after the glucose injection) were observed in comparison with young animals in similar experiments. Pancragen administration (50 μg/animal per day during 10 days, intramuscularly) to old monkeys caused markedly increased the glucose "disappear- ance" rate, normalized the plasma insulin and C-peptide dynamics in response to glucose administration. The recovering effect of Pancragen on the function of the pancreas partially remained 3 weeks after discontinuation of the drug. Thus, Pancragen is a promising factor for restoring the age-related endocrine dysfunction of primates.

Publication types

  • English Abstract

MeSH terms

  • Aging / blood
  • Aging / metabolism*
  • Animals
  • Blood Glucose / analysis
  • C-Peptide / blood
  • Female
  • Glucose / metabolism
  • Glucose Tolerance Test
  • Injections, Intramuscular
  • Insulin / blood
  • Insulin Resistance*
  • Islets of Langerhans / drug effects*
  • Islets of Langerhans / metabolism
  • Kinetics
  • Macaca mulatta
  • Oligopeptides / therapeutic use*


  • Blood Glucose
  • C-Peptide
  • Insulin
  • Oligopeptides
  • lysyl-glutamyl-aspartyl-tryptophanamide
  • Glucose