[Short peptides stimulate skin cell regeneration during ageing]

Adv Gerontol. 2014;27(4):699-703.
[Article in Russian]


The actual goal of gerontocosmetology is deal with the research of new effective and harmless low- molecular substances. The influence of LK and AEDG peptides in concentrations 0.05-2.00 ng/ml on organotypic skin cell cultures proliferation in young and old animals were investigated. Peptides stimulated skin fibroblasts proliferation on 29-45% in skin cell cultures of young and old rats. This effect was observed in smaller concentration diapason and level during skin ageing in old cell cultures as compared to young cell cultures. These data open new approach for creation cosmetology substances in the base of LKand AEDG peptides.

Publication types

  • English Abstract

MeSH terms

  • Aging / pathology
  • Aging / physiology*
  • Animals
  • Carnosine / pharmacology*
  • Cell Proliferation / drug effects
  • Fibroblasts / drug effects
  • Fibroblasts / physiology
  • In Vitro Techniques
  • Male
  • Oligopeptides / pharmacology*
  • Rats, Wistar
  • Regeneration / drug effects*
  • Skin / drug effects*
  • Skin / pathology
  • Skin Aging / drug effects*


  • Oligopeptides
  • Carnosine
  • alanyl-glutamyl-aspartyl-glycine