The protective effect of lipoic acid on selected cardiovascular diseases caused by age-related oxidative stress

Oxid Med Cell Longev. 2015;2015:313021. doi: 10.1155/2015/313021. Epub 2015 Apr 8.

Abstract

Oxidative stress is considered to be the primary cause of many cardiovascular diseases, including endothelial dysfunction in atherosclerosis and ischemic heart disease, hypertension, and heart failure. Oxidative stress increases during the aging process, resulting in either increased reactive oxygen species (ROS) production or decreased antioxidant defense. The increase in the incidence of cardiovascular disease is directly related to age. Aging is also associated with oxidative stress, which in turn leads to accelerated cellular senescence and organ dysfunction. Antioxidants may help lower the incidence of some pathologies of cardiovascular diseases and have antiaging properties. Lipoic acid (LA) is a natural antioxidant which is believed to have a beneficial effect on oxidative stress parameters in relation to diseases of the cardiovascular system.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aging / pathology*
  • Animals
  • Cardiotonic Agents / pharmacology
  • Cardiotonic Agents / therapeutic use*
  • Cardiovascular Diseases / drug therapy*
  • Cardiovascular Diseases / pathology*
  • Humans
  • Oxidative Stress* / drug effects
  • Thioctic Acid / pharmacology
  • Thioctic Acid / therapeutic use*

Substances

  • Cardiotonic Agents
  • Thioctic Acid