Finding small molecules for the 'next Ebola'

F1000Res. 2015 Feb 27;4:58. doi: 10.12688/f1000research.6181.2. eCollection 2015.


The current Ebola virus epidemic may provide some suggestions of how we can better prepare for the next pathogen outbreak. We propose several cost effective steps that could be taken that would impact the discovery and use of small molecule therapeutics including: 1. text mine the literature, 2. patent assignees and/or inventors should openly declare their relevant filings, 3. reagents and assays could be commoditized, 4. using manual curation to enhance database links, 5. engage database and curation teams, 6. consider open science approaches, 7. adapt the "box" model for shareable reference compounds, and 8. involve the physician's perspective.

Keywords: box model; databases; ebola; open science; outbreak; patents; text mining.